Protection against Lethal Influenza with a Viral Mimic
Identifieur interne : 000846 ( Main/Exploration ); précédent : 000845; suivant : 000847Protection against Lethal Influenza with a Viral Mimic
Auteurs : Steven F. Baker ; Hailong Guo ; Randy A. Albrecht ; Adolfo García-Sastre ; David J. Topham ; Luis Martínez-SobridoSource :
- Journal of Virology [ 0022-538X ] ; 2013.
Abstract
Despite countermeasures against influenza virus that prevent (vaccines) and treat (antivirals) infection, this upper respiratory tract human pathogen remains a global health burden, causing both seasonal epidemics and occasional pandemics. More potent and safe new vaccine technologies would contribute significantly to the battle against influenza and other respiratory infections. Using plasmid-based reverse genetics techniques, we have developed a
Url:
DOI: 10.1128/JVI.01081-13
PubMed: 23720727
PubMed Central: 3719819
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Despite countermeasures against influenza virus that prevent (vaccines) and treat (antivirals) infection, this upper respiratory tract human pathogen remains a global health burden, causing both seasonal epidemics and occasional pandemics. More potent and safe new vaccine technologies would contribute significantly to the battle against influenza and other respiratory infections. Using plasmid-based reverse genetics techniques, we have developed a <underline>s</underline>
ingle-<underline>c</underline>
ycle <underline>i</underline>
nfectious <underline>i</underline>
nfluenza <underline>v</underline>
irus (sciIV) with immunoprotective potential. In our sciIV approach, the fourth viral segment, which codes for the receptor-binding and fusion protein hemagglutinin (HA), has been removed. Thus, upon infection of normal cells, although no infectious progeny are produced, the expression of other viral proteins occurs and is immunogenic. Consequently, sciIV is protective against influenza homologous and heterologous viral challenges in a mouse model. Vaccination with sciIV protects in a dose- and replication-dependent manner, which is attributed to both humoral responses and T cells. Safety, immunogenicity, and protection conferred by sciIV vaccination were also demonstrated in ferrets, where this immunization additionally blocked direct and aerosol transmission events. All together, our studies suggest that sciIV may have potential as a broadly protective vaccine against influenza virus.</p>
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<name sortKey="Baker, Steven F" sort="Baker, Steven F" uniqKey="Baker S" first="Steven F." last="Baker">Steven F. Baker</name>
<name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name>
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<name sortKey="Martinez Sobrido, Luis" sort="Martinez Sobrido, Luis" uniqKey="Martinez Sobrido L" first="Luis" last="Martínez-Sobrido">Luis Martínez-Sobrido</name>
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